INTERACTION STUDY OF ALBENDAZOLE WITH HYDROXYPROPYL-β-CYCLODEXTRIN.
CRISTINA TRANDAFIRESCU1, Á. GYERESI 2, M. KATA 3,
Z. AIGNER3, Z. SZABADAI 4
1Victor Babeş University of Medicine and Pharmacy, Faculty of Pharmacy, Eftimie Murgu Str. Nr. 2, Timişoara, România
2University of Medicine and Pharmacy, Faculty of Pharmacy, Gheorghe Marinescu Str. Nr.38. Târgu-Mureş, România
3University of Szeged, Faculty of Pharmacy, Eötvös Str. Nr.6, Szeged, Hungary
4Victor Babeş University of Medicine and Pharmacy, Faculty of Pharmacy, Eftimie Murgu Str. Nr.2, Timişoara, România
Author for correspondence: Cristina Trandafirescu
e-mail: chimfarmatm@yahoo.com

Abstract:

Albendazole, an imidazole derivative, is an antihelminthic drug used for the treatment of systemic parasitosis. Its low hydrosolubility limits its dissolution and absorption and therefore, its oral bioavailability. One possible approach for improving the physico-chemical properties of a drug is the complexation with cyclodextrins.
The purpose of this study is to investigate the effect of hydroxypropyl-β-cyclodextrin in improving the solubility characteristics of albendazole and the possibility of complex formation, using differential scanning calorimetry.

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