ANALYSIS OF THE ACTIVITY OF PERIPLASMIC SUPEROXIDE DISMUTASE FROM TWO GRAM-NEGATIVE BACTERIA.
ELENA CRISTINA CRACIUN1, C. HODARNAU2, S. P. PAŞCA3
1Department of Pharmaceutial Biochemistry and Clinical Laboratory, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca, Pasteur Street, no. 6
2Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca
3Student - Faculty of Medicine, University of Medicine and Pharmacy “Iuliu Haţieganu”, Cluj-Napoca
Corresponding author e-mail: ecgagyi@yahoo.com

Abstract:

Superoxide dismutases (SODs) are vital metalloenzymes that constitute one of the major defense mechanisms of cells against oxidative stress. Gram-negative bacteria possess periplasmic Cu/ZnSOD which acts on superoxide anion to yield molecular oxygen and hydrogen peroxide, and contribute to their virulence towards the host. The aim of this paper was to determine if different growth conditions influences the activity of periplasmic Cu/ZnSOD from the bacteria Proteus mirabilis and Salmonella enteritidis.

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