ANALIZA FIZICO-CHIMICĂ A UNOR COMPLECŞI DE INCLUZIUNE AI CLORTALIDONEI CU β-CICLODEXTRINA.
CODRUŢA ŞOICA1, Á. GYÉRESI2, Z. AIGNER3, M. KATA3, CRISTINA DEHELEAN1, Z. SZABADAI1
1Universitatea de Medicină şi Farmacie „Victor Babeş” Timişoara, Facultatea de Farmacie, P-ţa Eftimie Murgu, nr.2
2Universitatea de Medicină şi Farmacie Târgu-Mureş, Facultatea de Farmacie, str. Gh.Marinescu, nr.38
3Universitatea din Szeged, Institutul de Tehnologie Farmaceutică, str. Eötvös nr.6, Ungaria

Abstract:

Chlorthalidone is a practically insoluble in water diuretic, used for the treatment of edema and hypertension. β-cyclodextrin was used as a host molecule to improve its solubility in water, via inclusion complex formation. In order to obtain the inclusion complexes, different molar ratios (1:1, 1:2) and various preparation methods (physical mixing, kneading, spray-drying) were used. Phase solubility diagram of chlorthalidone and β-cyclodextrin was constructed and a diagram of AL type was obtained, with a stability constant of 248 M-1. The inclusion complexes were analysed by X-ray diffraction and 13C NMR techniques. As the solubility in water increased, the partition coefficients of the products decreased.

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