SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN AND CAFFEINE IN PHARMACEUTICALS USING MULTIPLE CALIBRATION METHODS.
L.L. RUS1*, B. KISS2, I. TOMUŢĂ3, E. FĂGĂRĂŞAN4
UMF “Iuliu Haţieganu” – Cluj-Napoca, Faculty of Pharmacy, Emil Isac Street, No. 13
1Drugs Control Department
2Toxicology Departament
3Pharmaceutical Technology Department
4Physical Chemistry Department
*corresponding author: lrus@umfcluj.ro

Abstract:

This study involves the interplay of drugs control, spectrophotometry and chemometrics. It concerns the determination of acetaminophen and caffeine in pharmaceutical formulations. The spectra were measured in the spectral region 215-300 nm considering intervals Δλ = 1 nm. Two experimental designs were used. Prediction quality of those designs was discussed. Multiple regression was performed using PCR, PLS, PLS 1. The results of the methods were compared each other and with label value of commercial pharmaceutical formulation Panadol Extra and good agreement was found.

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