ANALIZA TERMICĂ (TG, DTG, DTA) ŞI SPECTRALĂ (FT-IR) ÎN STUDIUL STABILITĂŢII LISINOPRILULUI ÎN STARE SOLIDĂ. NOTA 1.
DANIELA CONSTANTINESCU¹, CRISTINA CRISTEA², ELENA CUREA^3
1S.C. Terapia S.A.
²S.C. Dragoner srl Sibiu
³Universitatea de Medicină şi Farmacie ”Iuliu Haţieganu” Cluj, Emil Isac, 13

Abstract:

Physico-chemical parameters of solid state represent quality criteria in substances availability and bioavailability evaluation.
Emphasizing transformations which active principles suffer under formulations technology factors influence represent a major objective of actual research.
It is studied Lisinopril dihydrate stability N-[N-(1S)-1-carboxy-3-phenyl-propyl]-L-lysil]-L-proline, itself and in binary combinations, active substance-ingredients (lactose, mannitol, calcium phosphate, starch, avicel, n-hydroxi propylmethylcellulose, magnesium stearate), by thermogravimetric analysis (TG/DTG)-derivative thermogravimetry and differential thermic analysis (DTA) şi spectrală (FT-IR).
Dehydration, hydrolitic degradation and the internal cyclization product which take place under pharmacotechnical factors and certain conditions of temperature, humidity, association capacity are studied on this work.

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